Assay Development Scientist

Jounce Therapeutics
Cambridge, MA

SCIENTIST, PRECLINICAL BIOASSAY GROUP
We are looking for a creative and highly motivated scientist to join the Preclinical Bioassay group at Jounce Therapeutics. The successful candidate will be an integral part of a team of scientists supporting the preclinical and clinical development of novel cancer Biologics. The primary responsibilities of the candidate will include the development of immunoassays for the analysis of PK/PD and properties of molecules currently in the Jounce pipeline. In addition, the candidate will be involved in designing and developing cell-based, mechanistic assays to support preclinical research and clinical development. The candidate will be responsible for the proper design and execution of experiments, data analysis and interpretation, thorough documentation of work, and clear communication of results both in group settings and in written reports. The candidate must be capable of working across functional groups and communicating results with scientists from diverse backgrounds. Lastly, the candidate must be a highly-motivated self-starter capable of working independently and as part of a team.

RESPONSIBILITIES

• Development and execution of bioanalytical and cell-based immunoassays to support development of novel immunotherapies from research through to clinical development stage.
• Thorough documentation of experiments and communication of results across functional teams.
• Drafting documents in support of regulatory filings.
• Mentoring and managing of a junior researcher.

REQUIREMENTS

• PhD in Immunology or a related field with 0-2 years of relevant laboratory experience, with industrial experience a plus.
• Experience and comfort with the isolation of immune cells from blood and tissue, testing therapeutics in cellular assays, and phenotyping of immune cells.
• Experience and comfort in developing and troubleshooting assays to assess pharmacokinetics, ADA responses, and target engagement.
• Extensive hands-on experience with immunological techniques including multi-parameter flow cytometry, single-cell sorting, immunoassays such as ELISA/MSD, in vitro cytotoxicity assays (ADCC & CDC), and reporter bioassays development.
• Able to work with human and animal tissue and blood or blood products.
• Proficient at independently designing and executing experiments, analyzing data, and reporting conclusions to team members.
• Familiarity with bioanalytical assay development and qualification processes.
• Excellent organizational and time management skills.
• Able to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines.
• Familiarity working in GxP environments is a plus.

COMPANY OVERVIEW
Jounce Therapeutics is an immuno-oncology company dedicated to transforming the treatment of cancer. The company is discovering and developing novel cancer immunotherapies designed to harness the immune system to attack tumors and provide long-lasting benefits to patients. Jounce integrates translational science insights including identification of related biomarkers designed to match the right immunotherapy to the right patients. The company is advancing programs that leverage contributions from its world-class founders as well as knowledge acquired from Jounce’s Translational Science Platform to create a sustainable “discovery to human proof-of-concept” product engine with the potential to drive significantly more durable responses to treatment. Founded by world leaders in tumor immunology, cancer biology and clinical and translational medicine, Jounce Therapeutics was launched in 2013 with funding from leading life sciences investor, Third Rock Ventures.

To be considered for this role, please submit your resume to Careers@JounceTx.com with the job title in the subject line of your email.

We are an equal opportunity employer offering a competitive salary and benefits package.

All applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited