Postdoctoral Position

The Scripps Research Institute, Department of Immunology and Microbiology 
La Jolla California

Our laboratory is interested in the functions of genes that promote autoimmune disease and also enhance tumor immunotherapy. A minor allele of PTPN22, a phosphatase that is expressed in all bone marrow derived cells, enhances the frequency of many autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and lupus. Using CRISPR, a line of NOD mice has been produced expressing this allele. This both accelerates disease and enhances its frequency. Our goal is to identify the underlying mechanism and also determine whether this can also be used to enhance immunotherapy.

Applicants with should send their CV to lsherman@scripps.edu with the subject line: Postdoctoral application.

Recent publications relevant to this research:

Maine CJ, Teijaro JR, Marquardt K, Sherman LA. PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection: Proc Natl Acad Sci U S A. 2016 Nov 5;113(46):E7231-E7239.

Lin, X. et. al. CRISPR-Cas9-Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes. Diabetes. 2016 Aug;65(8):2134-8.